Purpose: To review and reinforce your knowledge of the reactions of glycolysis, gluconeogenesis, the pentose phosphate pathway and the tricarboxylic acid (Krebs) cycle, as well remind you about some vitamin-coenzyme connections.
- Know the "bottom lines" of glycolysis, gluconeogenesis, pentose phosphate, the TCA cycle and the pyruvate dehydrogenase reaction.
- Reason from the pathways in clinical contexts and recognize the key regulatory steps in these pathways.
- Recognize why the intermediates -- and the enzymes that act on them -- have the names that they do.
- Apply knowledge of the pathways to clinical situations.
- Describe the following reactions:
Hexokinase Phosphofructokinase-1 Glyceraldehyde 3-phosphate dehydrogenase Pyruvate kinase Pyruvate dehydrogenase Isocitrate dehydrogenase α-ketoglutarate dehydrogenase Succinate dehydrogenase Glucose 6-phosphate dehydrogenase Pyruvate carboxylase Fructose 1,6-bisphosphatase Glucose 6-phosphatase
- Identify the four functions of the pentose phosphate pathway.
- Associate coenzymes with the vitamins from which they are produced and list reactions these coenzymes participate in.
- Distinguish between the concepts of coenzyme and vitamin.
- Recognize why compounds -- and the enzymes that act on them -- have the names they do.