Department of Biochemistry
 |
| Borries Demeler |
Borries Demeler, Associate Professor
| Education: | Ph.D; Oregon State University, Corvallis, 1992 |
|---|---|
| Post Doctoral: | The University of Texas, Health Science Center, 1993-1996 |
| Other Faculty Positions: | UTSA, Dept. of Computer Science |
| Web Page: | http://www.demeler.uthscsa.edu/ |
| Email: | demeler@biochem.uthscsa.edu |
| Phone: | (210) 567-6592 |
| Room: | 425D |
Our main project involves the development of the UltraScan data analysis software package (http://www.ultrascan.uthscsa.edu). This software is used for modeling of hydrodynamic and thermodynamic properties of biological and synthetic macromolecules, and interactions and thermodynamic characteristics of macromolecular assemblies. Areas of research involve advanced numerical analysis, optimization, high-performance network computing and cluster computing. Currently we are working on the development of software for the interpretation of multiwavelength sedimentation velocity experiments, and on spectral decomposition of analytical ultracentrifugation experiments. We are also investigating rigid body modeling approaches for predicting hydrodynamic properties of macromolecules and for the interpretation of small angle X-ray scattering data.
Selected publications:
- Cölfen H, Laue TM, Wohlleben W, Schilling K, Karabudak E, Langhorst BW, Brookes E, Dubbs B, Zollars D, Rocco M, Demeler B
The Open AUC Project.
Eur Biophys J: 2009-03-19; (); Epub: 2009-03-19.
PMID: 19296095 - Brookes E, Cao W, Demeler B
A two-dimensional spectrum analysis for sedimentation velocity experiments of mixtures with heterogeneity in molecular weight and shape.
Eur Biophys J: 2009-02-27; (); Epub: 2009-02-27.
PMID: 19247646 - Nagel-Steger L, Demeler B, Meyer-Zaika W, Hochdörffer K, Schrader T, Willbold D
Modulation of aggregate size- and shape-distributions of the amyloid-beta peptide by a designed beta-sheet breaker.
Eur Biophys J: 2009-02-24; (); Epub: 2009-02-24.
PMID: 19238376 - Brookes E, Demeler B, Rosano C, Rocco M
The implementation of SOMO (SOlution MOdeller) in the UltraScan analytical ultracentrifugation data analysis suite: enhanced capabilities allow the reliable hydrodynamic modeling of virtually any kind of biomacromolecule.
Eur Biophys J: 2009-02-21; (); Epub: 2009-02-21.
PMID: 19234696 - Cao W, Demeler B
Modeling analytical ultracentrifugation experiments with an adaptive space-time finite element solution for multicomponent reacting systems.
Biophys J: 2008-07-01; 95(1); 54-65 Epub: 2008-04-04.
PMID: 18390609
Lab Associations:
Bruce Dubbs, Systems Analyst IV
Jeremy Mann, Mr.
Virgil Schirf, XLA/SPR Core Facility
Dan Zollars, Staff